Dr. Anna Cereseto, the Principal Investigator of the Laboratory of Molecular Biology at the University of Trento will present a seminar “Advancing genome editing technologies for therapeutic applications” at the VU Life Sciences Center on January 17 (Friday) 10:00-11:00 EET in R101 auditorium.
Abstract:
Genome editing technologies hold great promise for clinical development, offering the potential to transform the treatment landscape for genetic disorders and diseases targeted by immunotherapies. By enhancing the precision and efficiency of gene therapies, these technologies lay the foundation for more personalized and advanced treatments. However, several challenges hinder the widespread adoption of genome editing in clinical practice. These challenges stem primarily from the limitations of CRISPR-based tools, including their low compatibility with commonly used delivery vectors, constraints on target sequences, immunogenicity, and unpredictable efficiency and precision across the genome.
Our recent work has focused on overcoming these obstacles by employing two key strategies: the discovery of novel CRISPR systems and the use of directed evolution approaches, coupled with molecular engineering to improve compatibility with gene therapy applications. In this presentation, I will outline the discovery pipeline we’ve developed to advance new genome editing tools and explore their potential applications for the treatment of cystic fibrosis, one of the most prevalent and debilitating genetic diseases.
There will be slots after the talk for individual meetings with researchers interested in collaboration with Dr. Anna Cereseto. Please contact Dalia to reserve the time: .
